Life Biosciences is starting a clinical trial of its cellular reprogramming therapy in humans
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Scientists at Life Biosciences are preparing to begin testing partial reprogramming in people. It will mark the first time such therapy, which can reset the biological age of cells, is being introduced in humans. Life Biosciences’ approach is partly based on the Yamanaka factors, a set of four transcription factors, namely Oct4, Sox2, Klf4, and c-Myc, which can reprogram an adult cell into an induced pluripotent stem (iPS) cell that can virtually become any cell type in the body. The Yamanaka factors worked well in mice, but there were concerns about their unknown potential in the body, especially with the c-Myc factor, which is particularly powerful and can trigger cancer. Life Biosciences to begin trial for cellular reprogramming on humans In the quest to experiment with safer ways to apply the Yamanka factors, Yuancheng Ryan Lu, a student of Harvard’s Dr. David Sinclair, the founder of Life Biosciences, successfully regenerated eye cells in mice by introducing just three of the factors, excluding the c-Myc factor. Story @nature about the challenge of discovering safe epigenetic reprogramming to reverse biological age, by my student Yuancheng Lu and now in clinical trials🤞Here’s that moment: https://t.co/NFXUtXDfYB pic.twitter.com/ssYTkffGvl — David Sinclair (@davidasinclair) April 11, 2026 Lu’s positive study in the mice forms the basis for Life Biosciences’ clinical trial targeting people with eye conditions due to aging. It will be the world’s first human trial, according to a recent report by Nature. The trial begins later this year and would treat up to 12 people with glaucoma. According to the report, the scientists will use a virus to introduce the three Yamanaka factors into one eye in patients whose retinal nerve has been damaged due to glaucoma. The team also plans to treat another 6 with NAION, which is reportedly the most common cause of…
Filed under: News - @ April 12, 2026 8:20 am