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Nikos Pekiaridis | Lightrocket | Getty Images Pfizer on Monday said it would end development of its experimental daily weight loss pill after a patient experienced a liver injury that was potentially caused by the drug in a trial.  The patient did not experience any liver-related symptoms or side effects, a Pfizer spokesperson said in a statement. They added that the patient’s liver enzymes “recovered rapidly” after they stopped taking the pill, which is an oral GLP-1 drug called danuglipron. The statement suggests that the patient’s liver enzymes were elevated, which often indicates damage to cells in the organ and is an issue that has been linked to some other obesity drugs. The case occurred in a trial that quickly increased the dose of the pill over a short period of time, the spokesperson said. Pfizer’s decision to halt development of the drug came after “a review of the totality of information, including all clinical data generated to date for danuglipron and recent input from regulators,” according to a release. “While we are disappointed to discontinue the development of danuglipron, we remain committed to evaluating and advancing promising programs in an effort to bring innovative new medicines to patients,” Dr. Chris Boshoff, Pfizer’s chief scientific officer, said in the release. He added that the company is still developing other weight loss drugs. The announcement adds to a string of setbacks in the company’s bid to win a slice of the booming market for GLP-1s, which mimic certain gut hormones to tamp down appetite and regulate blood sugar. Pfizer is among several drugmakers racing to bring a more convenient weight loss medicine to a space dominated by weekly injections, but it is years behind competitors such as Eli Lilly and Novo Nordisk. Some Wall Street analysts expect the GLP-1 industry to be worth more…

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Filed under: News - @ April 15, 2025 10:29 am